Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer.

Ligorio, Matteo; Sil, Srinjoy; Malagon-Lopez, Jose; Nieman, Linda T; Misale, Sandra; Di Pilato, Mauro; Ebright, Richard Y; Karabacak, Murat N; Kulkarni, Anupriya S; Liu, Ann; Vincent Jordan, Nicole; Franses, Joseph W; Philipp, Julia; Kreuzer, Johannes; Desai, Niyati; Arora, Kshitij S; Rajurkar, Mihir; Horwitz, Elad; Neyaz, Azfar; Tai, Eric; Magnus, Neelima K C; Vo, Kevin D; Yashaswini, Chittampalli N; Marangoni, Francesco; Boukhali, Myriam; Fatherree, Jackson P; Damon, Leah J; Xega, Kristina; Desai, Rushil; Choz, Melissa; Bersani, Francesca; Langenbucher, Adam; Thapar, Vishal; Morris, Robert; Wellner, Ulrich F; Schilling, Oliver; Lawrence, Michael S; Liss, Andrew S; Rivera, Miguel N; Deshpande, Vikram; Benes, Cyril H; Maheswaran, Shyamala; Haber, Daniel A; Fernandez-Del-Castillo, Carlos; Ferrone, Cristina R; Haas, Wilhelm; Aryee, Martin J; Ting, David T.

Cell ; 178(1): 160-175.e27, 2019 06 27.

Artigo em Inglês | MEDLINE | ID: mdl-31155233

2.

MEK inhibition reprograms CD8⁺ T lymphocytes into memory stem cells with potent antitumor effects.

Verma, Vivek; Jafarzadeh, Nazli; Boi, Shannon; Kundu, Subhadip; Jiang, Zhinuo; Fan, Yiping; Lopez, Jose; Nandre, Rahul; Zeng, Peng; Alolaqi, Fatmah; Ahmad, Shamim; Gaur, Pankaj; Barry, Simon T; Valge-Archer, Viia E; Smith, Paul D; Banchereau, Jacques; Mkrtichyan, Mikayel; Youngblood, Benjamin; Rodriguez, Paulo C; Gupta, Seema; Khleif, Samir N.

Nat Immunol ; 22(1): 53-66, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33230330

3.

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal.

Mitchell, Thomas J; Turajlic, Samra; Rowan, Andrew; Nicol, David; Farmery, James H R; O'Brien, Tim; Martincorena, Inigo; Tarpey, Patrick; Angelopoulos, Nicos; Yates, Lucy R; Butler, Adam P; Raine, Keiran; Stewart, Grant D; Challacombe, Ben; Fernando, Archana; Lopez, Jose I; Hazell, Steve; Chandra, Ashish; Chowdhury, Simon; Rudman, Sarah; Soultati, Aspasia; Stamp, Gordon; Fotiadis, Nicos; Pickering, Lisa; Au, Lewis; Spain, Lavinia; Lynch, Joanna; Stares, Mark; Teague, Jon; Maura, Francesco; Wedge, David C; Horswell, Stuart; Chambers, Tim; Litchfield, Kevin; Xu, Hang; Stewart, Aengus; Elaidi, Reza; Oudard, Stéphane; McGranahan, Nicholas; Csabai, Istvan; Gore, Martin; Futreal, P Andrew; Larkin, James; Lynch, Andy G; Szallasi, Zoltan; Swanton, Charles; Campbell, Peter J.

Cell ; 173(3): 611-623.e17, 2018 04 19.

Artigo em Inglês | MEDLINE | ID: mdl-29656891

4.

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal.

Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Horswell, Stuart; Chambers, Tim; O'Brien, Tim; Lopez, Jose I; Watkins, Thomas B K; Nicol, David; Stares, Mark; Challacombe, Ben; Hazell, Steve; Chandra, Ashish; Mitchell, Thomas J; Au, Lewis; Eichler-Jonsson, Claudia; Jabbar, Faiz; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Fernando, Archana; Stamp, Gordon; Nye, Emma; Stewart, Aengus; Xing, Wei; Smith, Jonathan C; Escudero, Mickael; Huffman, Adam; Matthews, Nik; Elgar, Greg; Phillimore, Ben; Costa, Marta; Begum, Sharmin; Ward, Sophia; Salm, Max; Boeing, Stefan; Fisher, Rosalie; Spain, Lavinia; Navas, Carolina; Grönroos, Eva; Hobor, Sebastijan; Sharma, Sarkhara; Aurangzeb, Ismaeel; Lall, Sharanpreet; Polson, Alexander; Varia, Mary; Horsfield, Catherine; Fotiadis, Nicos.

Cell ; 173(3): 595-610.e11, 2018 04 19.

Artigo em Inglês | MEDLINE | ID: mdl-29656894

5.

Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal.

Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Chambers, Tim; Lopez, Jose I; Nicol, David; O'Brien, Tim; Larkin, James; Horswell, Stuart; Stares, Mark; Au, Lewis; Jamal-Hanjani, Mariam; Challacombe, Ben; Chandra, Ashish; Hazell, Steve; Eichler-Jonsson, Claudia; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Fernando, Archana; Stamp, Gordon; Nye, Emma; Jabbar, Faiz; Spain, Lavinia; Lall, Sharanpreet; Guarch, Rosa; Falzon, Mary; Proctor, Ian; Pickering, Lisa; Gore, Martin; Watkins, Thomas B K; Ward, Sophia; Stewart, Aengus; DiNatale, Renzo; Becerra, Maria F; Reznik, Ed; Hsieh, James J; Richmond, Todd A; Mayhew, George F; Hill, Samantha M; McNally, Catherine D; Jones, Carol; Rosenbaum, Heidi; Stanislaw, Stacey; Burgess, Daniel L; Alexander, Nelson R; Swanton, Charles.

Cell ; 173(3): 581-594.e12, 2018 04 19.

Artigo em Inglês | MEDLINE | ID: mdl-29656895

6.

Author Correction: PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1⁺CD38^hi cells and anti-PD-1 resistance.

Verma, Vivek; Shrimali, Rajeev K; Ahmad, Shamim; Dai, Winjie; Wang, Hua; Lu, Sumin; Nandre, Rahul; Gaur, Pankaj; Lopez, Jose; Sade-Feldman, Moshe; Yizhak, Keren; Bjorgaard, Stacey L; Flaherty, Keith T; Wargo, Jennifer A; Boland, Genevieve M; Sullivan, Ryan J; Getz, Gad; Hammond, Scott A; Tan, Ming; Qi, Jingjing; Wong, Phillip; Merghoub, Taha; Wolchok, Jedd; Hacohen, Nir; Janik, John E; Mkrtichyan, Mikayel; Gupta, Seema; Khleif, Samir N.

Nat Immunol ; 20(11): 1555, 2019 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-31551574

7.

PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1⁺CD38^hi cells and anti-PD-1 resistance.

Verma, Vivek; Shrimali, Rajeev K; Ahmad, Shamim; Dai, Winjie; Wang, Hua; Lu, Sumin; Nandre, Rahul; Gaur, Pankaj; Lopez, Jose; Sade-Feldman, Moshe; Yizhak, Keren; Bjorgaard, Stacey L; Flaherty, Keith T; Wargo, Jennifer A; Boland, Genevieve M; Sullivan, Ryan J; Getz, Gad; Hammond, Scott A; Tan, Ming; Qi, Jingjing; Wong, Phillip; Merghoub, Taha; Wolchok, Jedd; Hacohen, Nir; Janik, John E; Mkrtichyan, Mikayel; Gupta, Seema; Khleif, Samir N.

Nat Immunol ; 20(9): 1231-1243, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31358999

8.

P53 and BCL-2 family proteins PUMA and NOXA define competitive fitness in pluripotent cell competition.

Valverde-Lopez, Jose A; Li-Bao, Lin; Sierra, Rocío; Santos, Elisa; Giovinazzo, Giovanna; Díaz-Díaz, Covadonga; Torres, Miguel.

PLoS Genet ; 20(3): e1011193, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38489392

9.

Molecular characterization of nervous system organization in the hemichordate acorn worm Saccoglossus kowalevskii.

Andrade López, José M; Pani, Ariel M; Wu, Mike; Gerhart, John; Lowe, Christopher J.

PLoS Biol ; 21(9): e3002242, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37725784

10.

Low-density lipoprotein promotes microvascular thrombosis by enhancing von Willebrand factor self-association.

Chung, Dominic W; Platten, Kimsey; Ozawa, Koya; Adili, Reheman; Pamir, Nathalie; Nussdorfer, Forrest; St John, Alexander; Ling, Minhua; Le, Jennie; Harris, Jeff; Rhoads, Nicole; Wang, Yi; Fu, Xiaoyun; Chen, Junmei; Fazio, Sergio; Lindner, Jonathan R; López, José A.

Blood ; 142(13): 1156-1166, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37506337

11.

In noncardiac thoracic surgery, low-dose colchicine did not reduce AF or myocardial injury after noncardiac surgery at 14 d.

Lopez, Jose; Borzak, Steven.

Ann Intern Med ; 177(1): JC3, 2024 01.

Artigo em Inglês | MEDLINE | ID: mdl-38163371

12.

Why sequence all eukaryotes?

Blaxter, Mark; Archibald, John M; Childers, Anna K; Coddington, Jonathan A; Crandall, Keith A; Di Palma, Federica; Durbin, Richard; Edwards, Scott V; Graves, Jennifer A M; Hackett, Kevin J; Hall, Neil; Jarvis, Erich D; Johnson, Rebecca N; Karlsson, Elinor K; Kress, W John; Kuraku, Shigehiro; Lawniczak, Mara K N; Lindblad-Toh, Kerstin; Lopez, Jose V; Moran, Nancy A; Robinson, Gene E; Ryder, Oliver A; Shapiro, Beth; Soltis, Pamela S; Warnow, Tandy; Zhang, Guojie; Lewin, Harris A.

Proc Natl Acad Sci U S A ; 119(4)2022 01 25.

Artigo em Inglês | MEDLINE | ID: mdl-35042801

13.

Standards recommendations for the Earth BioGenome Project.

Lawniczak, Mara K N; Durbin, Richard; Flicek, Paul; Lindblad-Toh, Kerstin; Wei, Xiaofeng; Archibald, John M; Baker, William J; Belov, Katherine; Blaxter, Mark L; Marques Bonet, Tomas; Childers, Anna K; Coddington, Jonathan A; Crandall, Keith A; Crawford, Andrew J; Davey, Robert P; Di Palma, Federica; Fang, Qi; Haerty, Wilfried; Hall, Neil; Hoff, Katharina J; Howe, Kerstin; Jarvis, Erich D; Johnson, Warren E; Johnson, Rebecca N; Kersey, Paul J; Liu, Xin; Lopez, Jose Victor; Myers, Eugene W; Pettersson, Olga Vinnere; Phillippy, Adam M; Poelchau, Monica F; Pruitt, Kim D; Rhie, Arang; Castilla-Rubio, Juan Carlos; Sahu, Sunil Kumar; Salmon, Nicholas A; Soltis, Pamela S; Swarbreck, David; Thibaud-Nissen, Françoise; Wang, Sibo; Wegrzyn, Jill L; Zhang, Guojie; Zhang, He; Lewin, Harris A; Richards, Stephen.

Proc Natl Acad Sci U S A ; 119(4)2022 01 25.

Artigo em Inglês | MEDLINE | ID: mdl-35042802

14.

Experimental High-Resolution Observation of the Truncated Double-Icosahedron Structure: A Stable Twinned Shell in Alloyed Au-Ag Core@Shell Nanoparticles.

Mendoza-Cruz, Rubén; Palomares-Báez, Juan Pedro; López-López, Stephan Mario; Montejano-Carrizales, Juan Martín; Rodríguez López, José Luis; José Yacamán, Miguel; Bazán-Díaz, Lourdes.

Nano Lett ; 24(14): 4072-4081, 2024 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-38557078

15.

The store-operated Ca²⁺ channel Orai1α is required for agonist-evoked NF-κB activation by a mechanism dependent on PKCß2.

Nieto-Felipe, Joel; Sanchez-Collado, Jose; Jardin, Isaac; Salido, Gines M; Lopez, Jose J; Rosado, Juan A.

J Biol Chem ; 299(2): 102882, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36623731

16.

Putative malignant hyperthermia mutation Ca_V1.1-R174W is insufficient to trigger a fulminant response to halothane or confer heat stress intolerance.

Feng, Wei; Lopez, Jose R; Antrobus, Shane; Zheng, Jing; Uryash, Arkady; Dong, Yao; Beqollari, Donald; Bannister, Roger A; Hopkins, Philip M; Beam, Kurt G; Allen, Paul D; Pessah, Isaac N.

J Biol Chem ; 299(8): 104992, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37392848

17.

Protamines and the sperm nuclear basic proteins Pandora's Box of insects.

Leyden, Melissa R; Gowen, Brent; Gonzalez-Romero, Rodrigo; Eirin-Lopez, Jose Maria; Kim, Bo-Hyun; Hayashi, Fumio; McCartney, Jay; Zhang, Patrick C; Kubo-Irie, Miyoko; Shabanowitz, Jeffrey; Hunt, Donald F; Ferree, Patrick; Kasinsky, Harold; Ausió, Juan.

Biochem Cell Biol ; 2024 Feb 26.

Artigo em Inglês | MEDLINE | ID: mdl-38408323

18.

A new physiological medium uncovers biochemical and cellular alterations in Lesch-Nyhan disease fibroblasts.

Escudero-Ferruz, Paula; Ontiveros, Neus; Cano-Estrada, Claudia; Sutcliffe, Diane J; Jinnah, H A; Torres, Rosa J; López, José M.

Mol Med ; 30(1): 3, 2024 Jan 03.

Artigo em Inglês | MEDLINE | ID: mdl-38172668

19.

Obesity and overweight as risk factors for low back pain in children and adolescents: a meta-analysis.

García-Moreno, José Manuel; Calvo-Muñoz, Inmaculada; Gómez-Conesa, Antonia; López-López, José Antonio.

Int J Obes (Lond) ; 48(5): 612-625, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38273033

20.

Removal of endothelial surface-associated von villebrand factor suppresses accelerate datherosclerosis after myocardial infarction.

Ozawa, Koya; Packwood, William; Muller, Matthew A; Qi, Yue; Xie, Aris; Varlamov, Oleg; McCarty, Owen J; Chung, Dominic; López, José A; Lindner, Jonathan R.

J Transl Med ; 22(1): 412, 2024 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-38693516

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